Pharmacology & Neuroscience

Rats in maze

Overview


Pharmacologists and neuroscientists play a crucial role in the understanding of brain function and in the development of new treatments for human and animal diseases. 
This often means studying the effects of drugs or other interventions and applying ethological techniques to the analysis of resulting behaviours.
Tracksys provides a range of complete systems for the automation of a wide variety of behavioural tests on laboratory animals using EthoVision XT and IR mazes
More sophisticated behaviours can be analysed using The Observer XT and externally acquired data such as ultrasonic vocalisations, EEG, heart rate, temperature etc can also be inputted into either EthoVision XT or The Observer XT to give a more complete picture of a disease model or drug treatment.

What do you need to do?

Observation Product
Score & analyse behaviours live or from videoThe Observer XT
Discover complex behavioural patterns & sequencesTheme
Measure ultrasonic vocalisationsUltraVox XT
Automatically monitor home cage behaviour of rodentsPhenoTyper
Track movement and location of animals within an arenaEthoVision XT
Assess the gait and footfalls of rodent models of diseasesCatWalk
Examine memory, anxiety, activity etc in various paradigmsIR Mazes

Recommended Products

EthoVision XT

EthoVision XT

EthoVision XT is the state-of-the-art video-tracking system that automatically records animal activity and movement, including motility and explorative behaviour.

CatWalk

CatWalk

A novel system for automated quantitative gait analysis in rodents. Objectively and rapidly measure a range of gait and individual paw parameters.

ErasmusLadder

ErasmusLadder

The ErasmusLadder is a system for the assessment of motor performance and motor learning in mice.

DanioVision

DanioVision

DanioVision is a complete solution, comprised of the DanioVision Observation Chamber and EthoVision XT with the Trial & Hardware Control Module and the Multiple Arenas Module pre-installed on a class-A computer.

UltraVox XT

UltraVox XT

Easy and affordable system
Full-spectrum sound capture with one microphone
Easy integration with other behavioral data
Real-time waveform and spectrogram
Automatic call detection
Easy definition and labeling of calls
Compact setup

The Observer XT

The Observer XT

A complete system for recording, review and analysis of behaviour, live or from video. Define, code, display and analyse behaviour quickly and easily with almost limitless flexibility. Used in research, teaching and training.

Observation Suites

Observation Suites

We design, install, support and provide training for a range of behavioural observation laboratories from simple one-camera systems through to complex usability labs. featuring screen capture, mouse and keyboard logging, automatic emotion measurement and eyetracking.

Automated Tube Test

Automated Tube Test

An automated system to test social heirachies in mice.

Coy MCS

Coy MCS

The Mechanical Conflict-Avoidance System – Harte, Morrow Method provides an operant method of pain testing in rodents

Example Scenarios

Here are some of the scenarios relevant to Pharmacology & Neuroscience and the products that would be appropriate.

Scenario Recommended Products
Social behaviour in group-housed animals

EthoVision XT

The Observer XT

Maternal separation studies and monitoring calling behaviour in rat pups

EthoVision XT

The Observer XT

UltraVox XT

Behavioural patterns in group-housed animals and hormone-behaviour interactions

EthoVision XT

Theme

The Observer XT

Home cage testing, activity monitoring and circadian studies in rodents

EthoVision XT

PhenoTyper

Avoiding problems with coat colour variation (e.g. transgenics), sequences of animals with different coat colours and urine reflections

EthoVision XT

IR Mazes

High-throughput screening (e.g. trials with 100+ zebrafish)

DanioVision

EthoVision XT

Passive avoidance and place preference tests

EthoVision XT

Resident-intruder and social interaction

EthoVision XT

Automation of the forced-swim test

EthoVision XT

Analysing pre-clinical drug effects

EthoVision XT

Case Studies

Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion De Visser L, Van den Bos R and Spruijt B.M.

The paper introduces PhenoLab as a tool to measure the effects of wheel running on the time distribution and daily organization of cage floor locomotor activity in mice.  To study these effects, female C57BL/6 mice were assigned to either a running wheel group or a control group with no running wheel. Observations of home cage behavior and running wheel activity were continuously recorded during bo...
Behavioral analysis of transgenic mice overexpressing corticotropin-releasing hormone using The Observer and EthoVision.

Behavioral analysis of transgenic mice overexpressing corticotropin-releasing hormone using The Observer and EthoVision. Dirks A, Groenink L, Verdouw M, van der Gugten J and Olivier B

Corticotropin-releasing hormone (CRH) plays a pivotal role in the response of an organism to various stressors. Furthermore, chronic elevated levels of CRH are implicated in human stress-related and affective disorders, including major depression. To gain more insight into the relationship between hyperactivity of the CRH system and associated neuroendocrine, autonomic, physiological and behavioral...

Theme in behavioural neuroscience - Hormone-behaviour interaction Hirschenhauser, K; Frigerio, D; Grammer, K & Magnusson, M.

Theme was used to question the assumed direct effect of testosterone on men's sexual behaviour. A co-occurrence of testosterone peaks and sexual activity was observed more often in prospective fathers than in men who had no partner or did not want to have children with their current partner.Prospective fathers were also different from other social groups in that they had a higher frequency of patte...

Using UltraVox to measure rat pup ultrasound vocalizations as an anxiolytic or anxiogenic evaluation procedure. McNee M, Gleason D and McArthur R

Maternal separation of rat pups is an ethopharmacologically validated model of anxiety and is measured by the duration and frequency of ultrasound vocalizations (USVs) made by the pups during this separation. These cries occur between 35 and 45 kHz, and have been described as "distress vocalizations" or "isolation calls".In this article we describe the use of UltraVox in order t...

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